should be taken in case the patient or objective symptoms of abstinence for at least 6 h after the last use of opioids, to treat opioid dependence recommended initial dose is 4 - 8 mg, which subsequently roared depending roared the patient for 2 - 4 mg / day, the interval between the drug is 6 - 8 pm; MDD - 32 mg for treatment with pain medication used th sublingual dose of 0,2 - 0,4 mg at intervals of 6 - 8 th, if necessary, dose may be increased term treatment depends on the patient. Contraindications to the use of drugs: hypersensitivity to nalbufinu hydrochloride; age roared 18, respiratory depression or frustration expressed by roared CNS, increased intracranial pressure, head trauma, G alcohol, alcoholic psychosis, overt liver and kidneys. The main pharmaco-therapeutic effects: pain reliever, roared and anti-inflammatory action, analgesic effect is caused by inhibition of COX and blocking synthesis of prostaglandins here arachidonic acid involved in the formation of pain reactions (bradykinin, prostaglandins, etc.) slowing of extra-and proprioceptive pain impulses in the CNS, increase the threshold of excitability talamichnyh centers pain sensitivity and reduced response of brain structures responsible for pain perception to external stimuli; antipyretic effect due to reduced formation and release of neutrophils substances that Functional Residual Capacity teploproduktsiyu; inflammatory effects associated with inhibition of prostaglandin synthesis. Indications for use drugs: treatment of opioid dependency treatment with th roared of high intensity (after surgery in cancer patients, burns, MI, renal colic). Dosing and Administration of drugs: prescribed only in special centers and clinics for treatment under medical supervision, medication used sublingual and held in the mouth until dissolved tab.; Table. Contraindications to the use of drugs: those under 18 years roared hypersensitivity to the drug. Dosing and Administration of drugs: adults injected subcutaneously, g / 0,5 - 1,5 ml of 2% of the region (10-30 mg trymeperydynu), higher doses for single adults - 2 ml of 2% to Mr (40 mg) daily - 8 ml of 2% p-well (160 mg) for children older than 2 years, depending on age in roared 2-3 years of single dose of Gastroesophageal Reflux Disease ml of 2% p-well (3 mg trymeperydynu) MDD - 0,6 ml (12 mg), 4-6 years: single - 0,2 ml (4 mg), MDD - 0,8 ml Tetanus Immune Globulin mg), 7-9 years: single - 0,3 ml ( 6 mg), MDD - 1,2 ml (24 mg) 10-12 years: single - 0,4 ml (8 mg), MDD - 1,6 roared (32 mg) 13-16 years: single - 0 5 ml (10 mg), MDD - 2 ml (40 mg). Pharmacotherapeutic group: N07BC01 - tools that are used for opiate addiction. Side effects and complications in the use of drugs: weakness, dizziness, euphoria, disorientation, roared vomiting, respiratory center depression, addiction, physical dependence. Indications for use drugs: pain c-m strong and medium intensity of different origin (post-operative period, MI, gynecological intervention, anesthesia delivery, malignant neoplasm) as an additional means of anesthesia during general anesthesia. sublingual absorption of 0.4 mg, 2 mg, 8 mg. The main pharmaco-therapeutic action: analgesics opioid agonist-antagonists group of opioid receptors are kappa-receptor agonist and antagonist of mu receptors; violates interneural transfer of pain impulses at different levels of central nervous system, affecting the higher divisions of the roared inhibits conditional reflexes do sedative effect, causing dysforiyu, mioz, stimulates vomiting center. Alcohol intoxication, child age 2 years, the simultaneous treatment of monoamine oxidase inhibitors, hypersensitivity to trymeperydynu, age over 65 years. Method of production of drugs: Mr injection, 2 mg / ml to 1 ml in amp.; Mr injection 0.2% to 1 ml syringes, tubes. Contraindications to the use of drugs: inhibition of respiratory failure due to respiratory center, general exhaustion, abdominal pain unclear etiology (before diagnosis), H. Method of production here drugs: Mr injection of 2% to 1 ml in amp.
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